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SARS-CoV-2 is a new threat to public health due to its increased transmissibility and immune evasion. Angiotensin-converting enzyme 2 (ACE2) plays a critical role in SARS-CoV-2 infection as its serve as the virus's major entry receptor in humans. Vaccines have been authorized for emergency use to control the current pandemic and they have greatly reduced the spread of SARS-CoV-2 and mortality rates, nevertheless this coronavirus has shown the ability to endure crucial mutations that increases its infectivity which makes it likely that the virus will continue to mutate and disseminate. There is a need to find and introduce alternative and effective methods of controlling SARS-CoV-2. Notably, low-level laser therapy (LLLT) is a method of exposing cells or tissue to low levels of red and near infrared light which has a high success rate for treatment of other ailments. The aim of the study is to determine for the first time, the effects of LLLT on SARS-CoV-2 infected HEK293/ACE2 cells and compare them to uninfected ones. Both infected and uninfected HEK293/ACE2 cells were irradiated at a wavelength of 640 nm, at different doses. Then, the effects of laser irradiation on the cells and the virus were evaluated using luciferase, cytotoxicity, and cell viability assays. Preliminary results showed that irradiated uninfected cells had no changes in cell viability and cytotoxicity, while there were changes in irradiated infected cells. In addition, laser irradiation caused cell membrane damage in infected cells. Lastly, uninfected irradiated cells showed no luciferase activity while laser irradiation reduced luciferase activity in infected cells. © 2023 SPIE.
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The International School on Quantum Electronics "Laser Physics and Applications” was held for the first time as far back as 1980. Since then it has taken place biennially and has become an important international event in the field of laser physics and laser applications attracting participants from many countries, especially from south-eastern Europe. Traditionally, its program includes lectures delivered by prominent scientists dealing with investigations of basic physical phenomena, processes of interaction of laser radiation with matter and latest scientific results obtained in the research areas of quantum electronics and optics, as well as the technological practical applications of new ideas, devices, instruments and laser systems. Special attention is paid to the active participation of students and young scientists who have the opportunity to present their results and meet and share experience with outstanding professionals in their particular fields of research.The topics include the following:• Laser-matter interactions• Laser spectroscopy and metrology• Laser remote sensing and ecology• Lasers in biology and medicine• Laser systems and nonlinear optics• Alternative techniques for material synthesis and processingThe 22nd edition of the ICSQE was held as a virtual forum due to the restrictions related to COVID-19 pandemic from September 19th to 23rd, 2022. The Institute of Electronics, Bulgarian Academy of Sciences, located in Sofia, Bulgaria, hosted the conference organization. The Big Blue Button on-line system was used as a technical platform for the meeting. The technical sessions of the International School on Quantum Electronics included 22 invited talks (30 min + 5 min Q&A), a Mini-Symposium "Extreme light infrastructure”, 11 oral contributions (30 min + 5 min Q&A) and in total 51 poster presentations divided into 5 sessions (1 hour each). The platform was available 24 hours, allowing discussions in addition to the technical program. The total number of participants was 90 from 16 countries.The XXII International Conference and School on Quantum Electronics: "Laser Physics and Applications” was held by the financial support from the Bulgarian National Science Fund under Project No. KP-06-MNF/4, 20.07.2022.List of Committees, International Advisory Committee, Program Committee, Local Organizing Committee, Lecturers, Oral Presentations, Poster Presentations are available in this pdf.
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Background: Hyaluronic acid fillers (HAF) are a versatile tool in esthetic medicine. They also have a potential for medical indications including facial rehabilitation. Materials and methods: We performed a literature search on PUBMED and Google Scholar until December 2022. Clinical trials, clinical studies, review articles, systematic reviews, meta-analyses, case series, and case reports were considered for review. Keywords "facial rehabilitation”, "acne scars”, "traumatic scars”, "oral restoration”, "facial lipoatrophy”, "facial asymmetry”, "periocular correction”, "nasal obstruction”, "ear lobe restoration”, "morphea”, AND "hyaluronic acid filler” were used to select articles. Results: We prepared a narrative review on the use of HAF for correction of facial asymmetry and asymmetric lips, improvement of different types of scars, improvement of the jaw line, improvement of ear lobes, periocular and oral restoration, and the treatment of nasal obstruction and morphea en coub de sabre. The amount of HA used in these indications is often less than 1 mL. The bolus technique, fanning, and dual-plane injections can be utilized for treatment. Duration of clinical effects depends upon the anatomical region and is usually maintained between 2 months and 2 years. Adverse events are often mild and temporary. Vascular occlusion is a severe adverse event, but it has not been reported yet for these medical indications. Repeated injections are recommended to obtain a longer-lasting improvement. In cases of morphea, only stable and non-inflammatory plaques should be treated. The advantage of HAF compared to permanent and semipermanent fillers is the availability of hyaluronidase for rapid removal of filler material and to revise overcorrection. Conclusions: HAF play an auxiliary role in facial rehabilitation. Knowledge of filler qualities, anatomy, and underlying diagnoses is important for their safe application. More prospective controlled trials are necessary to improve evidence.
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The increase in urban society in the use of cosmetic practices to rejuvenate oneself or obtain a more appealing appearance has influenced the practices of cosmetic dermatologists, general medical practitioners, plastic surgeons, and dental practitioners, among others. The pharmaceutical industry has evolved to meet customers' desire to be more physically attractive irrespectively of age and gender. This study aimed to preliminarily explore Jordanian adults' awareness of dental, facial, and other cosmetic procedures. The reasons for undergoing such cosmetic procedures and self-reported knowledge of the side effects or risks associated with these interventions were also explored. The results show that the participants had undergone various procedures to enhance their looks, attractiveness, and confidence. None of the female participants wanted to emulate a celebrity. Most participants were aware of the side effects associated with cosmetic procedures, which may be attributed to their educational backgrounds, as the participants' minimum qualification was 12th grade and their easy access to information services such as electronic media. A multicenter, large-scale, regional study is required to determine the associations, correlations, and recommendations for individuals seeking cosmetic treatment, cosmetic health providers, and policymakers.
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Ultrafast laser pump-probe spectroscopy is an important and growing field of physical chemistry that allows the measurement of chemical dynamics on their natural time scales, but undergraduate laboratory courses lack examples of such spectroscopy and the interpretation of the dynamics that occur. Here we develop and implement an ultrafast pump-probe spectroscopy experiment for the undergraduate physical chemistry laboratory course at the University of California Berkeley. The goal of the experiment is to expose students to concepts in solid-state chemistry and ultrafast spectroscopy via classic coherent phonon dynamics principles developed by researchers over multiple decades. The experiment utilizes a modern high-repetition-rate 800 nm femtosecond Ti:sapphire laser, split pulses with a variable time delay, and sensitive detection of transient reflectivity signals using the lock-in technique. The experiment involves minimal intervention from students and is therefore easy and safe to implement in the laboratory. Students first perform an intensity autocorrelation measurement on the femtosecond laser pulses to obtain their temporal duration. Then, students measure the pump-probe reflectivity of a single-crystal antimony sample to determine the period of coherent phonon oscillations initiated by an ultrafast pulse excitation, which is analyzed by fitting to a sine wave. Students who completed the experiment in-person obtained good experimental results, and students who took the course remotely due to the COVID-19 pandemic were provided with the data they would have obtained during the experiment to analyze. Evaluation of student written and oral reports reveals that the learning goals were met, and that students gained an appreciation for the field of ultrafast laser-induced chemistry. © 2022 American Chemical Society and Division of Chemical Education, Inc.
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Survey data are commonly cited as evidence of widespread misperceptions and misinformed beliefs. This paper shows that surveys generally fail to identify the firm, deep, steadfast, confidently held beliefs described in leading accounts. Instead, even those who report 100% certain belief in falsehoods about well-studied topics like climate change, vaccine side effects, and the COVID-19 death toll exhibit substantial response instability over time. Similar levels of response stability are observed among those who report 100% certain belief in benign, politically uncontested falsehoods—for example, that electrons are larger than atoms and that lasers work by focusing sound waves. As opposed to firmly held misperceptions, claims to be highly certain of incorrect answers are best interpreted as "miseducated” guesses based on mistaken inferential reasoning. Those reporting middling and low levels of certainty are best viewed as making close-to-blind guesses. These findings recast existing evidence as to the prevalence, predictors, correction, and consequences of misperceptions and misinformed beliefs.
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We propose and demonstrate an optical chaos secured optical body area network (OBAN) employing polarization multiplexing and free space optics links. The physiological data of patient coded in non-return to zero on-off keying (NRZ-OOK) format from two on-body nodes modulated on orthogonal polarization states of a continuous wave (CW) laser is secured by using additive chaos masking (ACM) technique with chaotic waveforms generated through direct modulation of semiconductor chaotic lasers (CLs). After polarization multiplexing, the secure NRZ- OOK modulated optical signals are transmitted over indoor and outdoor free space optics (FSO) links based on GammaGamma channel model towards remote healthcare center. After chaos subtraction, the NRZ-OOK modulated optical signals are photodetected and passed on to bit error rate (BER) estimator for performance analysis. The electronic health (e-health) system based on the proposed OBAN provides adequate privacy for classified patient related information with added advantages of acceptable BER results, cost efficiency, speedy installation and suitable for use in current pandemic situation. © 2022 IEEE.
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19–20 September 2022, Penang, MalaysiaThe Photonics Meeting is an annual event organized by the Optical Society of Malaysia (OSM) in celebrating UNESCO International Day of Light. For this year, the 5th Photonics Meeting 2022 (PM22) was held on 19th and 20th of September 2022 in collaboration with Universiti Sains Malaysia. PM22 with the theme "Exploring photonics breakthrough for humanity” has attracted 26 contributors that covers various topics on photonics including optical materials, laser physics, fiber optics and colorimetry. PM22 has been honoured with presentation from world renowned scientists from industry as well as international research laboratory and universities as the plenary and keynote speakers. PM22 would like to extend its great appreciation to all the committee members who have work diligently to ensure the smooth deliverance of this scientific event. Due to the Covid19 pandemic, the conference was fully conducted virtually through Cisco Webex platform hosted by School of Physics, Universiti Sains Malaysia. Each participant was given 10 minutes for their presentation and another 5 minutes for question and answer session. All submission has been thoroughly reviewed by the experts in the respective field and presented in this volume of Journal of Physics: Conference Series.List of Editors, Keynote Speaker, Plenary Speaker, Organizing Committee are available in this Pdf.
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The conference on electro, physical and chemical machining happened as ISEM XXI again in Zurich and was actually meant to become a full presence conference. The COVID-19 situation enforced again at least a hybrid conference, where approximately 40% of the contributions were made via internet. ISEM covers different manufacturing processes that have all in common, that the tool is non-mechanical, but defined by partial differential field equations together with boundary conditions, which represent at least partly the workpiece. This general description is the bracket around those processes and makes it valuable to combine contributions to the development of electro machining, physical machining and chemical machining and also combinations as hybrid processes within one conference. As the modelling of the processes and the prediction of process results becomes increasingly important, the conference provides a cross fertilization between approaches to different processes. But the processes have more in common than is generally believed. © 2022 The Authors. Published by Elsevier B.V.
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Epitaxy has remained a crucial step in MtM applications such as Power GaN, Power SiC, MicroLED and VCSELs. With COVID-19 accelerating the technological curve for these applications, the capital investment in the epitaxy equipment space is booming. In addition, the dynamic geo-political situation has added an additional level of demand for epitaxy equipment as device manufacturers in China are spending on equipment at record levels. In this paper, we aim to provide an overview of the status and market forecast for the epitaxy equipment (MOCVD, HTCVD and MBE) in MtM space, along with a brief outlook on the role of China in the equipment demand and how it is shaping the competitive landscape of epitaxy equipment vendors. © 2022 MANTECH 2022. All rights reserved.
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While three-dimensional digital renderings of cultural heritage sites have been developed over the past decades for informational and preservation purposes, the COVID 19 pandemic has demonstrated that the audience for virtual cultural heritage – so-called “technoheritage” – is likely to grow, engaging lay persons and specialist scholars alike through creative renditions and experiences of digital sites. Virtual availability affords democratized access to cultural heritage sites in theory, yet the process of digitizing heritage raises questions of intellectual property rights and how they should be allocated among the various stakeholders, including site stewards and heritage recording organizations. This article untangles these knotty intellectual property issues and posits that the current trend to treat all technoheritage and related data as copyrightable intellectual property is a clunky approach and not legally sound. Understanding the intellectual property in and to technoheritage and addressing intellectual property allocation in the complex manner the law requires are crucial to finding workable solutions that can balance concerns regarding appropriation of cultural heritage with open access to information.
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A practical tapered optical fiber (TOF) biosensing system was developed for label-free detection using antigen-antibody pairs with repeatable results and a very high degree of sensitivity. This was done by attaching molecular recognition agents to a tapered fiber surface for augmenting sensitivity and specificity of analyte. The entire system included three main parts: a tunable laser, a tapered fiber, and an optical detector. Light from an unpolarized tunable fiber laser was introduced into the tapered fiber from one end, and the transmitted intensity was detected by a photodetector. In the tapered fiber area, the evanescent electromagnetic field, which extends outside the fiber, was able to detect minute changes in the refractive index caused by antigen-antibody pairs. Recorded data was analyzed using an innovative Fourier analysis method to find phase changes, which are directly related to the biomolecular concentration coated on fiber, from which antibody-antigen concentrations are obtained. Two experiments were performed to confirm the concept using two very different agents. The first was the protein Interleukin-8 (IL-8). Repeatable results with a sensitivity of 10 pg/mL were achieved. The second was human coronavirus OC43 (HCoV-OC43), a surrogate viral particle for SARS-CoV-2, with a sensitivity of 50 viruses/mL. Critical sources of error were identified and addressed for the purpose of using the device for real clinical diagnosis in various real-life environments, where viruses can reside in water, phosphate-buffer solution, or saliva, the most popular three environments in real clinical diagnosis. Our device was designed according to the principle that only one specific kind of antibody and antigen can be combined together. The device demonstrated good accuracy to chosen analyte(s) tailored to specific applications and offered the potential to develop a point-of-care device used in clinics, as well as for detecting a variety of viruses and biocontaminants. The reproducibility of TOFs was confirmed through multiple fabrications and consistent results. [ FROM AUTHOR] Copyright of Optical Engineering is the property of SPIE - International Society of Optical Engineering and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)
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The air quality of the living area influences human health to a certain extent. Therefore, it is particularly important to detect the quality of indoor air. However, traditional detection methods mainly depend on chemical analysis, which has long been criticized for its high time cost. In this research, a rapid air detection method for the indoor environment using laser-induced breakdown spectroscopy (LIBS) and machine learning was proposed. Four common scenes were simulated, including burning carbon, burning incense, spraying perfume and hot shower which often led to indoor air quality changes. Two steps of spectral measurements and algorithm analysis were used in the experiment. Moreover, the proposed method was found to be effective in distinguishing different kinds of aerosols and presenting sensitivity to the air compositions. In this paper, the signal was isolated by the forest, so the singular values were filtered out. Meanwhile, the spectra of different scenarios were analyzed via the principal component analysis (PCA), and the air environment was classified by K-Nearest Neighbor (KNN) algorithm with an accuracy of 99.2%. Moreover, based on the establishment of a high-precision quantitative detection model, a back propagation (BP) neural network was introduced to improve the robustness and accuracy of indoor environment. The results show that by taking this method, the dynamic prediction of elements concentration can be realized, and its recognition accuracy is 96.5%.
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During the period of prevailing unsettled COVID pandemic, the countries and states started to plan reopening during which necessitates the non-contact temperature evaluation gadgets as a part of a preliminary look at access points to identify the humans with elevated body temperatures. Despite the utilization of these devices, temperature assessment restricted the impact on lowering the spread of COVID-19. Non-contact temperature measuring devices are used to measure the temperature of any person. Detection of a high temperature is one huge manner to pick out a person who might also have COVID-19 contamination. In this project, a room environment is created in which certain precautions are taken. A laser diode and receiver are used to detect the entrance of a person, and the system also detects the body temperature of the entering person. If the temperature is less than a threshold temperature entry for the person is permitted or else the entry is denied. This system also has a feature where it permits only a pre-determined number of persons inside the room. It also facilities to view the allowed temperature, the number of people to be allowed in the room and the number of people present actively using a Bluetooth App. This system aimed to be useful to combat the spread of COVID infections. © 2022 IEEE.
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Rapid, selective, and highly sensitive microelectromechanical sensors are a promising technology for biosensing, medical recognition, and the detection of chemical hazards. At the same time, the surfaces of silicon microcantilevers cannot bond with thiols and cannot be functionalized without a bonding layer, such as gold. Therefore, in past literature, the surfaces of silicon microcantilevers have been coated with gold to facilitate their bonding with the thiol functional groups on the probe layers. However, gold coating produces thermal noise in the results owing to the metallic effect. Accordingly, this study aimed to modify the surface of silicon microcantilevers by patterning it using femtosecond laser (FSL) micromachining so that it could bond with the thiol functional groups with high sensitivity. The surface patterning of silicon microcantilevers enhances their physical, micromechanical, and chemical properties, increasing sensitivity by increasing the quality factor, specific surface area, and creating trapping areas on the microcantilever surfaces. The surfaces of the silicon microcantilever were patterned by microgrooves aligned from the free end to the bounded end, with each microgroove comprising submicrogrooves. To demonstrate their use in a biosensing applications, the modified microcantilevers were functionalized to detect severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2;COVID-19) by immobilizing thiolated oligonucleotides on the surfaces, which worked as the probe layer. The modified biosensor was used to detect low concentrations of SSDNA sequence targets ranging from 300 nM down to 100 pM. The modified silicon-microcantilever sensors were directly functionalized without a joining layer, such as a gold layer. The results revealed a selective response to SARS-CoV-2 SSDNA down to a 9-nM concentration. To detect hazardous chemicals, the modified microcantilever was functionalized using reduced L-cysteine to detect Pb2+ at low concentrations down to 100 pM. The results revealed enhanced sensitivity and selectivity and demonstrated that the FSL patterning activated the microcantilevers to bond with probe layers through the interaction of the silanol created on the surface with the functional groups, such as the thiols, on the probe layers. The microcantilevers patterned with 10 microgrooves exhibited higher responses than those patterned with seven microgrooves. © 2022 John Wiley & Sons Ltd.
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Purpose>A harvesting robot is developed as part of kiwifruit industry automation in New Zealand. This kiwifruit harvester is currently not economically viable, as it drops and damages too many kiwifruit in the harvesting task due to the positional inaccuracy of the gripper. This is due to the difficulties in measuring the exact effective dimensions of the gripper from the manipulator. The purpose of this study is to obtain the effective gripper dimensions using kinematic calibration procedures.Design/methodology/approach>A setup of a constraint plate with a dial gauge is proposed to acquire the calibration data. The constraint plate is positioned above the robot. The data is obtained by using a dial gauge and a permanent marker. The effective dimensions of the gripper are used as error parameters in the calibration process. Calibration is exercised by minimizing the difference between target positions and measured positions iteratively.Findings>The robot with the obtained effective dimensions is tested in the field. It is found that the fruit drops due to positional inaccuracy of the gripper are greatly reduced after calibration.Practical implications>The kiwifruit industry in New Zealand is growing rapidly and announced plans in 2017 to double global sales by 2025. This growth will put extra pressure on the labour supply for harvesting. Furthermore, the Covid pandemic and resulting border restrictions have dramatically reduced seasonal imported labour availability. A robotic system is a potential solution to address the labour shortages for harvesting kiwifruit.Originality/value>For kiwifruit harvesting, the picking envelope is well above the robot;the experimental data points obtained by placing a constraint plate above the robot are at similar positions to the target positions of kiwifruit. Using this set of data points for calibration yields a good effect of obtaining the effective dimension of the gripper, which reduces the positional inaccuracy as shown in the field test results.
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[...]based on the improved financial performance and cash flow position, the Credit Rating Agencies CARE Ratings and ICRA Limited have upgraded the Company's credit rating from AA+ Stable to AAA/Stable during the financial year. HAL and BEL sign contract for indigenous IRST HAL and BEL signed a contract for co-development and coproduction of Long Range Dual Band Infra-Red Search and Track System (IRST) for Su-30 MKI on 26 April 2022 under the MAKEII procedure of Defence Acquisition Procedure (DAP) 2020, as part of the 'Make in India' initiative. The proposed IRST system will be a high end strategic technology product in the field of defence avionics and technically competitive to existing IRST system in the global market with features of Television Day Camera, Infrared and Laser sensors in single window for air to air and air to ground target tracking and localisation.
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Despite the availability of GNSS on consumer devices enabled personal navigation for most of the World population in most of the outdoor conditions, the problem of precise pedestrian positioning is still quite challenging when indoors or, more in general, in GNSS-challenging working conditions. Furthermore, the covid-19 pandemic also raised of pedestrian tracking, in any environment, but in particular indoors, where GNSS typically does not ensure sufficient accuracy for checking people distance. Motivated by the mentioned needs, this paper investigates the potential of UWB and LiDAR for pedestrian positioning and tracking. The two methods are compared in an outdoor case study, nevertheless, both are usable indoors as well. The obtained results show that the positioning performance of the LiDAR-based approach overcomes the UWB one, when the pedestrians are not obstructed by other objects in the LiDAR view. Nevertheless, the presence of obstructions causes gaps in the LiDAR-based tracking: instead, the combination of LiDAR and UWB can be used in order to reduce outages in the LiDAR-based solution, whereas the latter, when available, usually improves the UWB-based results.
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In the past few decades, nanotechnology has been receiving significant attention globally and is being continuously developed in various innovations for diverse applications, such as tissue engineering, biotechnology, biomedicine, textile, and food technology. Nanotechnological materials reportedly lack cell-interactive properties and are easily degraded into unfavourable products due to the presence of synthetic polymers in their structures. This is a major drawback of nanomaterials and is a cause of concern in the biomedicine field. Meanwhile, particulate systems, such as metallic nanoparticles (NPs), have captured the interest of the medical field due to their potential to inhibit the growth of microorganisms (bacteria, fungi, and viruses). Lately, researchers have shown a great interest in hydrogels in the biomedicine field due to their ability to retain and release drugs as well as to offer a moist environment. Hence, the development and innovation of hydrogel-incorporated metallic NPs from natural sources has become one of the alternative pathways for elevating the efficiency of therapeutic systems to make them highly effective and with fewer undesirable side effects. The objective of this review article is to provide insights into the latest fabricated metallic nanocomposite hydrogels and their current applications in the biomedicine field using nanotechnology and to discuss the limitations of this technology for future exploration. This article gives an overview of recent metallic nanocomposite hydrogels fabricated from bioresources, and it reviews their antimicrobial activities in facilitating the demands for their application in biomedicine. The work underlines the fabrication of various metallic nanocomposite hydrogels through the utilization of natural sources in the production of biomedical innovations, including wound healing treatment, drug delivery, scaffolds, etc. The potential of these nanocomposites in relation to their mechanical strength, antimicrobial activities, cytotoxicity, and optical properties has brought this technology into a new dimension in the biomedicine field. Finally, the limitations of metallic nanocomposite hydrogels in terms of their methods of synthesis, properties, and outlook for biomedical applications are further discussed.
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*Correspondence – Olivia Li: o.li@nhs.netTo generate a personalised prognostic model to predict keratoconus progression to corneal collagen cross-linking (CXL).Methods and AnalysisIn this retrospective cohort study, we recruited 5,025 patients (9,341 eyes) with early keratoconus between January 2011 and November 2020. Genetic data from 926 patients was available. We evaluated both change in keratometry or CXL as indices of progression and used the Royston-Parmar method on the proportional hazards scale to generate a prognostic model. We calculated hazard ratios (HR) for each significant covariate, with explained variation and discrimination.ResultsAfter exclusions, model-fitting comprised 8,701 eyes, of which 3,232 underwent CXL. For early keratoconus CXL provided a more robust prognostic model than keratometric progression. The final model explains 33% of the variation in time-to-event age HR [95% confidence limits] 0.9 [0.90–0.91], maximum anterior keratometry (Kmax) 1.08 [1.07–1.09], and minimum corneal thickness 0.95 [0.93–0.96] as significant covariates. Single nucleotide polymorphisms (SNPs) associated with keratoconus (n=28) did not significantly contribute to the model. The predicted time-to-event curves closely followed the observed curves during internal-external validation.ConclusionsA prognostic model to predict keratoconus progression could aid patient empowerment, triage and service provision. Age at presentation is the most significant predictor of progression risk. Candidate SNPs associated with keratoconus do not contribute to progression risk.